Research Articles
ASO vs siRNA: A Comprehensive Microarray Analysis Guide for Specificity Assessment in Therapeutic Development
This article provides researchers, scientists, and drug development professionals with a detailed framework for evaluating the specificity of Antisense Oligonucleotides (ASOs) and small interfering RNAs (siRNAs) using microarray analysis.
ASO vs siRNA: A Comprehensive Guide to Specificity in Gene Silencing Microarray Analysis
This article provides a detailed comparative analysis of antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) for targeted gene silencing, with a specific focus on specificity profiling using microarray technology.
Optimized ASO Transfection Protocol for In Vitro Cell Culture: A Step-by-Step Guide for Researchers
This comprehensive guide details a robust protocol for Antisense Oligonucleotide (ASO) transfection in mammalian cell culture, targeting research scientists and drug development professionals.
Harnessing ASO Technology to Modulate Nonsense-Mediated mRNA Decay: A Strategic Guide for Therapeutic Development
This article provides a comprehensive technical resource for researchers, scientists, and drug developers focusing on Antisense Oligonucleotides (ASOs) targeting pre-mRNA to modulate Nonsense-Mediated Decay (NMD).
Mitigating Off-Target Effects in Antisense Oligonucleotides: A Practical Guide for Researchers
This comprehensive article addresses the critical challenge of non-specific protein binding in Antisense Oligonucleotide (ASO) therapeutics.
Mastering DNA Simulation: The Complete Guide to AMBER Force Field Parameters for 2024
This comprehensive guide provides researchers, scientists, and drug development professionals with essential knowledge for simulating DNA using the AMBER force field.
From Sequence to Function: How Deep Learning Models Decode Gene Expression Prediction
This comprehensive review explores the cutting-edge intersection of artificial intelligence and genomics, focusing on deep learning models that predict gene expression directly from DNA sequence.
ADAR1 vs ADAR2: Decoding Catalytic Specificity, A-to-I Editing Mechanisms, and Therapeutic Implications
This article provides a comprehensive comparative analysis of the catalytic activity and substrate selectivity of ADAR1 and ADAR2, the two catalytically active adenosine deaminases acting on RNA.
Harnessing ADAR-Recruiting Oligonucleotides: A Next-Generation Strategy for Programmable RNA Editing
This article provides a comprehensive overview of the rapidly evolving field of ADAR-recruiting oligonucleotides (AROs) for precise RNA base editing.
ADAR Editing vs. ASOs: A Comprehensive Comparison of Mechanisms, Efficacy, and Clinical Translation
This article provides a detailed comparative analysis of ADAR-mediated RNA editing and antisense oligonucleotide (ASO) technologies for therapeutic gene modulation.