Research Articles
CHARMM36 Nucleic Acid Force Field: A Comprehensive Guide for Modern Biomolecular Simulation
This guide provides researchers and drug development professionals with a detailed overview of the CHARMM36 nucleic acid force field, covering its foundational principles, practical application workflows, common troubleshooting strategies, and...
Mapping the Dark Genome: CAGE Analysis for Precise lncRNA Transcription Start Site Identification
Long non-coding RNAs (lncRNAs) represent a vast, functionally diverse component of the transcriptome implicated in gene regulation and disease.
Beyond the Data Deluge: Navigating the Top 5 Bioinformatics Challenges in Large-Scale NGS Analysis
The exponential growth of Next-Generation Sequencing (NGS) data presents unprecedented opportunities and formidable challenges for biomedical research and drug discovery.
BigHorn Machine Learning: Predicting lncRNA-DNA Interactions for Advanced Genomics and Drug Discovery
This article provides a comprehensive analysis of the BigHorn machine learning platform for predicting long non-coding RNA (lncRNA) and DNA interactions.
PCR Contamination Prevention: Essential Strategies for Reliable Molecular Diagnostics and Research
This comprehensive guide details the most current and effective best practices for preventing PCR contamination, targeting researchers, scientists, and drug development professionals.
RNA-Seq vs. Microarrays: A Comprehensive Guide to Superior Gene Expression Analysis in Modern Research
This article provides researchers, scientists, and drug development professionals with a definitive comparison of RNA sequencing (RNA-Seq) and microarray technologies for gene expression analysis.
NGS Library Prep Kit Showdown 2024: A Comprehensive Benchmarking Guide for Researchers
Selecting the optimal Next-Generation Sequencing (NGS) library preparation kit is a critical, yet complex, decision that directly impacts data quality, cost, and project success.
Reverse Transcription in RT-PCR: A Comprehensive Guide for Researchers and Drug Development
This article provides a detailed examination of reverse transcription, the critical first step in RT-PCR, tailored for researchers, scientists, and drug development professionals.
Beyond Perfect Matches: A Guide to siRNA Off-Target Prediction Using BLAST Analysis for Reliable Gene Silencing
This guide provides a comprehensive overview of BLAST analysis for siRNA off-target prediction, a critical step in therapeutic siRNA development.
BGISEQ-500 vs Illumina HiSeq 2500/3000: A Comprehensive 2024 Comparative Guide for Whole Genome Sequencing
This article provides a detailed, evidence-based comparison of the BGISEQ-500 and Illumina HiSeq 2500/3000 platforms for whole-genome sequencing (WGS).